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10.1016/s0928-4257(97)89480-6 102 SelyeH.SzaboS

The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance

Broad restrictive diets may worsen these pathways if protein and micronutrient intake become inadequate