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A prevalent idea is that opioid tolerance is a complex, multifaceted process that likely involves the interplay of multiple regulatory mechanisms occurring both at the level of individual opioid-responsive cells and at the level of neural circuits

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Extensive research involving transgenic mouse models (APP, 5FAD, SAMP8), Drosophila melanogaster , and human clinical trials has demonstrated their potential in reducing A burden, improving cognitive function, and restoring neuronal health

Do A, Nguyen TH, Pham Q, Nguyen H, Phuoc Long N, Vu V

The toxicity can be explained by the tendency of these molecules to bind or destroy important biomolecules