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468 Specifically, these agents can attenuate the excitability of carotid body cells and diminish sympathetic activation, ultimately leading to a reduction in sympathetic responses

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The treatment would also be injected once per week

Methods Male (n = 23) and female (n = 23) mice aged 7 (young) and 17 (aged) months were assigned to sedentary control, voluntary wheel running, or forced treadmill exercise

That is a different story from spacing doses under supervision. What structured de-escalation is and what it is not The authors described reduced-frequency maintenance as structured de-escalation that could reduce treatment burden without sacrificing key outcomes, at least in selected patients