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They noted that whey and casein, both proteins found in cows milk, increased GLP-1 secretion

These include nausea or mild upset stomach, allergic skin reactions, and rarely more serious allergic responses

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Most patients notice initial appetite changes between days 3-7, but meaningful suppression typically develops during weeks 2-3 as medication levels stabilize

These pathways rely on cofactors like vitamin B6, folate, and BH4 (tetrahydrobiopterin)

Whilst DPP-4 inhibitors improve glycaemic control, they produce less pronounced effects on appetite and weight compared to GLP-1 receptor agonists