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212 A long-term (4.5 year) multicenter study of nearly 5,000 patients with a previous heart attack and high total cholesterol levels demonstrated that a commercial red yeast rice preparation reduced the incidence of major coronary events, including nonfatal heart attack and cardiovascular mortality, when compared with placebo

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[] These novel biological approaches emphasize altering the biofilm to arrest carious lesions and include a range of procedures from stepwise excavation to nonrestorative caries treatment