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When To Take High-Dose Vitamin B12 Supplements Treating Vitamin B12 Deficiency People take high-dose vitamin B12 to treat a vitamin deficiency (levels below 200 to 250 pg/mL)

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When it comes to the functioning of your cells, methyl groups are used in methylation reactions.[ref] Examples of methylation reactions include: synthesis of some of the nucleic acid (DNA) bases turning off genes so that they arent transcribed (DNA methylation) converting serotonin into melatonin methylating arsenic so that it can be excreted breaking down neurotransmitters metabolizing estrogen regenerating methionine from homocysteine Methylation in the right amount: For example, you need enough folate (vitamin B9) and methylcobalamin (vitamin B12) for the methionine synthase reaction to occur

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It was unregulated access without physician oversight, and that risk doesnt go away no matter what the regulatory status becomes