They serve as key signaling molecules in the microbiota-gut-brain axis, directly influencing the central nervous system by crossing the BBB and indirectly modulating neurophysiological processes through immunoregulatory, endocrine, vagus nerve-mediated, and circulatory pathways
In this comprehensive overview (see Methods and the search methodology in Supplementary Section 1), we aim to identify and describe pre-clinical, mechanistic and clinical studies on the effects of GLP-1RAs in cognitive and mental health disorders, and to provide a summary of available evidence and future perspectives
Other GLP-1s and related agents Dulaglutide, exenatide and other GLP-1 RAs used primarily for diabetes generally produce modest weight loss compared with the agents above
There are illegal online pharmacies selling GLP-1 medications and those medications are not checked for safety
In turn, the levels of IGF-1 have been shown to be associated with an increased risk of cancer (204, 205)
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