These uricosuric drugs function, at high doses, by competing for urate reuptake from the glomerular filtrate via SLC22A12 and, therefore, reduce renal reabsorption of uric acid allowing for increased excretion in the urine
Among which, glucose-6-phosphate isomerase (GPI), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (GPMI) and phosphoglycerate kinase (PGK) were three most differentially expressed genes, showing the value of log2 fold-change (log2FC) 3.48, 3.46 and 2.85, respectively, at 3 DPI vs CK (Additional file 1: Dataset S1)
Current WADA status should be verified for competitive athletes
Avoid large, heavy meals for the first few days
Improves the overall performance of the immune system
Weight loss: Immediate appetite suppression, visible loss 6-12 weeks