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Furthermore, patients have significantly lower neurological improvement rates when tPA is administered in the morning compared to the evening, as well as increased hemorrhagic transformation post thrombolytic intervention during morning time points

This reflects a more balanced view of potential aspiration risks against proven therapeutic benefits, especially for diabetes and cardiovascular care [11, 12]

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The active effects may be short, but detection windows can vary depending on dosage, frequency of use, metabolism, and testing methods