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10.2.6 GLP-1 Receptor Antagonist 10.2.6.1 Mechanism of Action The two main incretin hormones, GIP and GLP-1, are released predominantly from L and K cells (in the proximal and distal intestine) following nutrient ingestion promoting insulin secretion, glucagon release inhibition, delaying gastric emptying, and enhancing satiety (resulting in weight control) with GLP-1 being much more effective than GIP (Van Genugten et al

Nearly two-thirds of participants on Tirzepatide lost at least 20% of their baseline weight, a magnitude not previously seen with GLP-1only therapy (Jastreboff, New England Journal of Medicine )

NAC is a precursor to glutathione, so it's fine to take it alongside glutathione

Amazon's oral GLP-1 option at $149 per month is competitive for patients who prefer an oral format and are willing to pay separately for consultations

Most patients see 20-60% improvement depending on the marks age and chosen treatment

After graduating college at USF, I received a Fulbright Fellowship and lived abroad for some years