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All data are presented as mean S.E.M

Key Differences: Efficacy and Dosage *SURMOUNT-5 head-to-head trial, NEJM 2025

It reviews their mechanisms of action, semaglutide acting as a GLP-1 receptor agonist and tirzepatide functioning as a dual GIP/GLP-1 receptor agonist, and explains how these pathways translate into clinical outcomes

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Abstract Vascular disruption has been implicated in coronavirus disease 2019 (COVID-19) pathogenesis and may predispose to the neurological sequelae associated with long COVID, yet it is unclear how bloodbrain barrier (BBB) function is affected in these conditions

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