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Edaravone regulated Postn in the attenuation of detrimental effects induced by hypobaric hypoxia There are 265 coregulated DEGs by hypobaric hypoxia and edaravone treatment or prevention in hippocampus, the GO analysis showed significant enrichment of biological processes included oxidative stress (response to oxygen-containing compound, response to superoxide, response to oxygen radical, and cellular oxidant detoxification), neurogenesis (cell differentiation, neurogenesis, neuron differentiation, and negative regulation of neural precursor cell proliferation), inflammation (phagocytosis) and cell adhesion (Figure S4A)

Ludot M, Mouchabac S, Ferreri F