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A phase I/II clinical trial found that the most common side effects were mild and transient (Teichman et al., 2006): Injection site reactions (redness, mild swelling) Headaches Flushing or warmth Temporary water retention Joint tightness or tingling Transient fatigue or dizziness Serious adverse events are rare when the peptide is used under medical supervision at appropriate doses

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While GLP-1 drugs have existed since the early 2000s, semaglutide revealed their potential beyond diabetes, particularly in obesity, where past treatments were often found inadequate

G.LaulettaG.et al (2019)