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A study published in PLOS ONE demonstrated that topical application of a tetravalent peptide resolved eczema in mouse models within 14 days, restoring normal epidermal morphology

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Although protein-SSG formation occurs by nonenzymatic mechanisms, the de-glutathionylation of proteins is mainly catalyzed by Grxs 32

Furthermore, GLP-1 and its analog (Ex-4) enhanced DNA repair and protected cortical neurons in brains of rats after ischemia which were due to up-regulation of apurinic/apyrimidinic endonuclease 1 (APE1) mediated by PI3K/AKT/CREB pathway (100)