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But because those studies followed different groups of people over different periods of time, researchers eventually compared the medications head-to-head in a roughly 16-month clinical trial involving more than 750 adults with obesity

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Biomarkers tested Beyond behavioral testing, the researchers conducted extensive analysis of brain tissue, measuring various crucial markers: [1] Brain-derived neurotrophic factor (BDNF) Key neurotransmitters (acetylcholine, dopamine, GABA) Antioxidant markers (catalase, glutathione) Beta-amyloid levels Cyclic GMP This comprehensive approach allowed the research team to not only observe behavioral outcomes but also understand the underlying neurochemical changes driving these effects

A., Dunn, J., Haupt, A., Milicevic, Z., & Coskun, T