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S2-SN38 and C-SN38 were generated via direct nucleophilic substitution of SN-38 with intermediates 1 and 2 , yielding 20% and 30%, respectively

Specifically, AHK-Cu might increase the expression of Bcl-2, an anti-apoptotic molecule, while reducing the levels of Bax, a pro-apoptotic counterpart

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The number of follicles was determined by recording the number of oocyte nuclei in all sections 60,61

The Nrf2 signaling pathway responds to oxidative stress by upregulation of antioxidants like glutathione (GSH) to compensate the stress insult and re-establish homeostasis

This stacking concept is explored further in the stacking strategies section below