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Science 359, 11511156

That means a BMI of 30 or higher, or a BMI of 27 or higher plus a weight-related health problem (such as obstructive sleep apnea)

Apart from intrinsic signaling, the TME shapes CSCs behavior and mechanical cures from ECM further modulates CSC fate, with poor stiffness enhancing stemness and high stress leading to quiescence via distinct integrin-dependent pathways