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Although these methods have demonstrated encouraging results in small-scale studies involving MS patients and EAE models, the absence of large-scale prospective randomized controlled trials means that these findings still suffer from limited reproducibility and challenges in generalizability across diverse populations

A diet based on whole foods, including oily fish, vegetables, olive oil, nuts, and wholegrains, has the strongest observational evidence for RA

Data from the surpass trial series revealed that tirzepatide reduces the risk of major adverse cardiovascular events and improves blood pressure, lipid profiles, and inflammatory markers (60, 61)

The prevalence of gastrointestinal adverse events was similar between NA-931 and placebo groups

Insurance coverage is the difference between affordable and prohibitively expensive for most patients

However, comprehensive long-term human safety data does not exist