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Exenatide reduces adiposity by promoting lipolysis, fatty acid oxidation and mitochondrial biogenesis in the WAT of obese mice When challenged with HFD, the weight of epididymal fat from C57BL/6J mice increased dramatically compared with normal controls, and decreased remarkably with exenatide treatment (Fig

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Notably, KPC mice are particularly small for age and fragile and exhibit limited physiological resilience, rendering them susceptible to intensified treatment regimens

In addition to pancreatic localization, GLP-1R has been found in the gastrointestinal system, kidneys, central nervous system, and cardiovascular system (Pyke et al., 2014)

Although these findings were encouraging, further randomized, controlled trials are needed to verify them