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Intestinal immune cell-derived overactivation of NOX and inducible nitric oxide synthase (iNOS) generates excessive ROS, which oxidatively damage tight junction proteins in epithelial cells, compromising intestinal barrier integrity

Wesseling, H., Rahmoune, H., Tricklebank, M., Guest, P

While TCM holds considerable promise, its clinical application is often limited by poor bioavailability and restricted penetration of the BBB

Moreover, it acts as a nitrogen donor in purine and pyrimidine synthesis as well as a precursor for protein and glutathione biosynthesis [23]

10.1016/j.cca.2019.02.022 34 OsburnW.WakabayashiN.MisraV.NillesT.BiswalS.TrushM.et al (2006)

Key takeaways Pentadeca arginate refers to a 15-amino-acid synthetic peptide in arginine salt form, the same core sequence originally identified in human gastric juice and studied in research contexts for decades