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This represents a gap in the evidence base that researchers should acknowledge when making decisions about protocol adoption

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Six months or more after stopping tirzepatide, outcomes vary: Some people maintain most of their weight loss Others regain part or most of the weight Long-term metabolic health depends heavily on lifestyle, sleep, stress, and activity levels The difference is rarely motivation, its planning and support

Researchers have long feared that GCGR agonism would lead to hyperglycemia

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