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Among these, NEF108 significantly ameliorated the symptoms and pathological changes of DSS-induced colitis and reduced DSS-induced IL-1 expression, suggesting that IL-6R is a potential therapeutic target in UC [105]

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In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response ( 3.2 Intestinal mucosal barrier IELs are a heterogeneous population of T cells located among intestinal epithelial cells (IECs), where they contribute to maintaining mucosal barrier integrity (59, 60)

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Injection site reactions are common, and the lack of standardised formulations means ingredient quality and sterility cannot be guaranteed outside regulated healthcare settings