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Description

Kimmelman, A

Impaired FAD-dependent enzyme activity is also detrimental to bloodbrain barrier (BBB) integrity, leading to downregulation of tight-junction proteins such as claudin-5 and occluding, increased permeability, and enhanced peripheral immune infiltration

However, it remains unclear whether copper accumulation in senile plaques of AD patients is a cause or a consequence of pathological processes observed in AD

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