For weight management, at least 5% weight loss from baseline after 12 weeks on maintenance dose is required to continue treatment
Metabolism of lactate has been proposed to support mitochondrial respiration even in the absence of mitochondrial import of cytoplasmic pyruvate
For example, multiple neuroimaging studies have reported increased brain lactate levels in patients with bipolar disorder [194,195,196,197]
Current Evidence on Glutathione and GLP-1 Stacking A 2023 review in the journal Nutrients examined glutathione's role in metabolic disease and found its benefits primarily in cell culture and animal studies, not human weight loss trials
SUSTAIN 6 (NCT01720446) was a multi-center, multi-national, placebo-controlled, double-blind cardiovascular outcomes trial
doi: 10.1038/s41467-017-02488-y