Theres no outright prohibition on alcohol (unlike some medications where its dangerous), but the combination of high alcohol intake and GLP-1 could increase risk of pancreatitis, and it can also contribute to weight stalling because of the extra calories
It is not surprising that hepatic T3 signaling has a metabolic effect similar to those observed after nutrition ingestion on incretin GLP-1 through the regulation of CYP8B1 and non-12-OH FXR-antagonistic BAs
That being said, most patients notice these side effects after first receiving an injection or receiving an increased dose
Its certainly something to bear in mind when consulting your patients, particularly where they may have been receiving botox prior to starting weight loss medication
If the pinch test produces less than half an inch of tissue at your usual spot, consider transitioning to a site with more subcutaneous depth
Aim for at least 64 ounces of water daily, sipped throughout the day rather than consumed in large amounts at once
