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While transient ER stress activates adaptive signaling that supports cell survival, sustained or severe ER stress shifts UPR signaling toward pro-apoptotic pathways involving CHOP induction, calcium overload, mitochondrial dysfunction, and caspase activation
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Address correspondence to: Mansoor Husain, Toronto General Hospital Research Institute, 101 College Street, TMDT Room 3-909, Toronto, Ontario, M5G 1L7, Canada
Our board-certified physicians encourage all our patients to understand the critical role antioxidants play in protecting and enhancing brain functions and no antioxidant is more potent than glutathione
Therefore, early detection of TLS in the kidney could identify patients who would benefit from prompt treatment