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When enough anomalies accumulate, they create what Kuhn calls a crisis, a loss of confidence in the status quo because the existing paradigms no longer apply

Building these physical structures is a process that takes days to weeks to complete, unlike stimulants that act on receptors and take effect within seconds or minutes

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The sarco/endoplasmic reticulum calcium ATPase pump transports intracellular calcium into the sarcoplasmic or endoplasmic reticulum of the cardiac, skeletal, and vascular smooth muscle cells

On the other hand, preclinical studies in rodents have shown that co-administration of a long-acting GIPRA synergistically enhances the glucose-lowering and weight-reducing effects of GLP-1RA (44, 75)