Volume 20, Issue 6, 1382-1393.e19
Related Reading Best Time of Day to Take Semaglutide for Weight Loss Does GLP-1 Make You Tired How Long Does It Take for GLP-1 to Work GLP-1 Dosage for Weight Loss GLP-1 Constipation How Long Does It Take for Semaglutide to Suppress Appetite Download our GLP-1 app to Turn Your Weight Loss Journey into Your Favorite Game Some people report changes to their cycle, like missed periods or irregular periods, when taking semaglutide
Thats because 2
By tracking patients for nearly a year and a half, SURMOUNT-5 demonstrated that the Tirzepatide advantage persists through the typical weight loss trajectory and into the maintenance phase
Research has identified these alarming vision-related risks associated with GLP-1 medications: Sudden irreversible vision loss: NAION strikes without warning, often discovered upon waking, causing blurry or dim vision that progresses to immediate and permanent partial or complete blindness in the affected eye with no possibility of restoration Elevated risk across multiple studies: Beyond the Harvard findings showing 4-7 fold increased risk, a University of Southern Denmark study examining over 424,000 patients found weekly semaglutide users faced 2.19 times higher NAION risk European regulatory recognition: In June 2025, the European Medicines Agency officially recognized NAION as a possible side effect of semaglutide medications, marking formal acknowledgment by international regulators Complete absence of treatment options: Medical science currently offers no cure, no effective treatment, and no way to reverse NAION-related vision damage, leaving patients with permanent disability The permanent and irreversible nature of NAION-related optic nerve damage distinguishes these injuries from other complications that may resolve after discontinuing medication
Preempted by federal law means that federal regulations take precedence over state laws, preventing states from enforcing their own laws if they conflict with federal rules
