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Phase 2: Introduce AOD 9604 (weeks 5-8) Once tirzepatide is tolerated at the initial dose, add AOD 9604 at 250mcg daily

0.5 s (Asn 402, *P = 0.0201) respectively for single knockouts and 0.6 s (Asn 247/Asn 395, P = 0.0694)

6.5 min, 80% B

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Purified Water, Butylene Glycol, Niacinamide, Propanediol, Hydroxyethyl Urea, Glycerin, Betaine, Trehalose, C12-14 Pareth-12, Caprylyl Glycol, Polyglyceryl-10 Laurate, Glutathione (1000ppm), Allantoin, Dipropylene Glycol, Fragrance, Caprylic/Capri Triglyceride, Ethylhexyl Glycerin, Adenosine, Phosphatidylcholine, Hydrogenated Lecithin, 1,2 Hexanediol, Disodium Idithio A Phytosteryl/Octyldodecyllauroyl Glutamate, Eucalyptus Leaf Extract, Perilla Leaf Extract, Ceramide NP, Sodium Hyaluronate, Ascorbic Acid, Tocopherol