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Senapati J, Almanza EH, Kadia TM, Montalban-Bravo G, Faderl S, Sasaki K, Short N, Daver N, DiNardo CD, Masarova L, Ferrajoli A, Jabbour E, Borthakur G, Azzawi HA, Konopleva M, Garcia-Manero G, Andreeff M , Kantarjian H, Ravandi F, and Alvarado A

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This is consistent with previous findings that -cell plasticity occurs in common forms of -cell dysfunction, and is caused by the downregulation of FoxO1 that follows hyperglycemia-induced oxidative stress 26