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While severe hypoglycemia is uncommon with tirzepatide monotherapy due to its glucose-dependent mechanism, combining it with other glucose-lowering agents or supplements increases risk

The LEADER trial 28 (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) studied a 1.8-mg dose in more than 9,000 patients with type 2 diabetes and found the incidence of acute pancreatitis was similar between the liraglutide and placebo groups (0.4% vs 0.5%, respectively)

Some patients may take semaglutide (Ozempic) off-label for weight loss

While semaglutide and tirzepatide primarily reduce food intake through appetite suppression, retatrutide simultaneously increases energy expenditure

doi: 10.1016/j.taap.2008.08.013 141 BridgesHRJonesAJPollakMNHirstJ

Large US claims database analyses continue to refine our understanding of both absolute and relative risk compared to other diabetes therapies