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GLP-1 receptors are found in brain regions associated with reward and pleasure, so by modulating these pathways, semaglutide and tirzepatide may influence the rewarding aspects of food consumption

The degree to which leptin and insulin stimulate overall GLP-1 secretion is still unclear, but GIP-mediated GLP-1 release has been shown to occur in rodents via acetylcholine release by the enteric nervous system

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The rats were received ginseng for four weeks