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At pH 5.7, the histidine imidazole (pKa ~6.0) remains predominantly deprotonated and available for copper coordination

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Additionally, direct supplementation of monounsaturated fatty acids (MUFAs) in the diet to replace PUFA, which is prone to lipid peroxidation on cell membranes, can prevent the accumulation of lipid ROS and the occurrence of ferroptosis [295]

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