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Tingling or numbness: Mild paresthesia in the extremities, related to fluid shifts and usually resolving within days

The primary adverse events are typically gastrointestinal in nature

Post-translational modifications, especially those in the DNA binding domain of FOXO4 protein, appear to modify its functionality as a transcription factor and regulation of pathways such as apoptosis, cellular senescence, insulin signaling, and senescence

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Moreover, recent studies showed that 1540% of IBD patients suffer from obesity, which becomes an increasing problem in IBD treatment

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