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doi: 10.1016/j.physbeh.2016.05.036

GLP-1 and GIP receptor agonists act in such a way that they increase the effectiveness of the other when used together

5.6 Sodium Imbalance in Patients with Acquired HO and Central Diabetes Insipidus In a clinical trial of adults and pediatric patients aged 4 years and older with acquired HO and concomitant central diabetes insipidus (DI)/arginine vasopressin (AVP) deficiency, hyponatremia was reported in 6% of IMCIVREE-treated patients and 2% of placebo-treated patients, and hypernatremia was reported in 5% of IMCIVREE-treated patients and 4% of placebo-treated patients

Severe side effects are rare, and the benefits of using Semaglutide often outweigh the potential risks, especially under medical supervision

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