In the HIV trial, treatment with weight-loss drugs slowed the rate of biological aging by about 9% compared with the placebo
The Incretin Effect helps maintain energy homeostasis 1
"I still live with the disease of obesity," he explains, meaning his natural tendency to gain weight remains
Studies of animal models have shown that such heterozygotes have a higher incidence of cardiomyopathy with aging and may be at risk for cardiac abnormalities when additional cardiac burdens are imposed.37), 38) A genetic epidemiological study in Japan showed that the prevalence of heterozygotes for SLC22A5 mutations was 1.01%, and the echocardiography analysis revealed that they were predisposed to late onset benign cardiac hypertrophy (odds ratio 15.1, 95% CI 1.39-164) compared with wild-types.9) However, a recent study examined the prevalence of heterozygotes for SLC22A5 mutations in 324 patients with cardiomyopathy and demonstrated that heterozygosity for PCD is not more frequent in patients with unselected types of cardiomyopathy and is unlikely to be an important cause of cardiomyopathy.27) Finally, heterozygosity for PCD mutations has been associated with cardiac arrhythmias that resolve after carnitine treatment.39) In any case, considering that about 1% of the population is heterozygous for this potentially treatable condition, more studies with careful follow-ups are deserved in the future
Monitor blood ketones weekly if optimization is a priority
All told, weve read more than 100 scholarly articles on testosterone deficiency and treatment, as well as nearly 100 more on various weight loss approaches, including GLP-1 receptor agonists like the ones Henry offers
