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IGF-1 gene transfer to CCl 4 -induced rat models alleviates hepatocyte premature senescence and fibrogenesis To evaluate the effect of IGF-1 on hepatocyte premature senescence and liver fibrosis, IGF-1 lentiviral vector was transferred to CCl 4 -induced rat models to overexpress IGF-1 of liver
Graphical Abstract Keywords Liver, Cardiovascular system, Metabolite, Extracellular vesicle, Hepatokine Introduction Although remarkable advances have been made in clinical and basic research fields, cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality, and impose a significant global health care burden
doi: 10.3389/fimmu.2022.952639 57 HanCGuanLXuL
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