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Still, real-world intake can drift with picky eating, frequent diet rotation, or chronic GI issues that change absorption

Transdermal estradiol, delivered through patches or gels rather than oral tablets, bypasses the liver entirely, avoiding the first-pass hepatic metabolism that oral estrogen undergoes and that is associated with increased clotting factor production and thrombotic risk

These reductions appeared partially independent of weight loss, suggesting potential direct anti-inflammatory effects