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The phase 2 dose-ranging trial (NCT02970942) included 320 individuals with histologically proven MASH and hepatic fibrosis F1-F3, randomizing them 3:3:3:1:1:1 to daily subcutaneous administration of semaglutide 0.1, 0.2, or 0.4 mg, or placebo for 72 weeks [18]

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However, he accepted that his weight came with the risk of serious health complications and was motivated to make changes

If the lower-nausea signal holds up in Phase 3, eloralintide may eventually become a meaningful option for patients who cannot tolerate GLP-1 medications