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In certain instances, a hyaluronidase described herein is a recombinant hyaluronidase

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For example, insufficient production of the protective compound butyrate reduces its anti-inflammatory and anti-fibrotic effects by inhibiting NF-B pathway [89]

Moreover, compared to c[Glu 22 Lys 26 ] Gly 8 GLP-1, the affinity and activity of c[Asp 22 Lys 26 ] Gly 8 GLP-1 are lower while those of c[hGlu 22 Lys 26 ] Gly 8 GLP-1 are higher (hGlu: homoglutamic acid), 36 indicating that the length of the amino acid side chain is an important factor

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Therefore, they allow for consistent and controlled delivery