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Pathogenic overgrowth activates inflammatory (via TLR-mediated IL-1, TNF-, IL-6 overproduction) and oxidative stress pathways: pro-inflammatory cytokines promote cervical ripening, induce matrix metalloproteinases (MMPs) to degrade fetal membrane collagen, while reactive oxygen species (ROS) directly damage structural proteins, compromising membrane integrity

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1 Its massively complicated. You have changes in your peripheral systems (neurons and immune cells), which make your spinal cord neurons hyperexcitable

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However, this direct connection between redox signaling and the Wnt/-catenin signaling needs to be further evaluated in hair cells

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