In: Shils M.E., Olson J.A., Shike M., Ross A.C., editors
According to local media reports, given how the NMPA managed similar medications in the past, its highly likely that weight-related eligibility requirements will be applied
Animal Toxicology Studies Animal toxicology studies tested doses from 0.0027 mg/lb to 9.1 mg/lb via intraperitoneal, intramuscular, intravenous, and oral routes for up to 6 weeks, finding: No acute toxic or lethal dose No gross or histologic toxicity in major organs No hepatotoxicity or nephrotoxicity Negative Ames test (no mutagenicity) Negative chromosomal aberration tests (no genotoxicity) No teratogenicity in rat pregnancy studies No local injection site irritation The LD1 (minimum lethal dose) could not be achieved despite aggressive testing
The news: Walgreens is rolling out a weight management program that includes access to GLP-1 medications via telehealth
Physiology & Behavior Aoun L, et al
The program includes community support, nutrition resources, and provider oversight through asynchronous check-ins