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p 90% on RAASi and -blockers, and 70% on MRA), and 50% of participants had T2D

Rectal body temperature Conscious mice were restrained and a high-precision thermometer (BIO-TK8851, Bioseblab) was carefully inserted half-way into the rectum

injections of 200 nmol kg 1 MK-801 (n = 8 mice and n = 4 cages), 600 nmol kg 1 MK-801 (n = 7 mice and n = 4 cages) or vehicle (isotonic saline, n = 7 mice and n = 4 cages) for 7 days

When prescribed safely and monitored by a provider, they are considered effective treatments for weight management and blood sugar control

The Lancet Diabetes & Endocrinology , 2017;5(5):355-366

Month 2: Visible changes begin appearing as the body adjusts to improved metabolic function