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doi: 10.1007/s00259-006-0184-5 181 Schartum-HansenHPedersenERSvingenGFUelandPMSeifertREbbingMet al

Thus, the Ser/Thr kinase AMPK is activated during energy depletion, when the AMP/ATP ratio increases and triggers a large number of downstream effectors by stimulating ATP-generating catabolic pathways and inhibiting anabolic pathways in order to restore the energy balance

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Distinguishing between these two helps you respond appropriately