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Clinical guidance recommends using additional forms of contraception, such as condoms or other barrier methods, for four weeks after initiating tirzepatide and for four weeks after each dose increase

Less common : gallbladder issues, raised heart rate, pancreatitis (rare)

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Safety Profile Enlicitide was generally well tolerated

however, glucagon receptor agonism can also raise blood glucose, and the net metabolic effect in this triple combination is still being characterised

Preliminary Phase I trials have shown a differentiating clinical profile for ECC5004, with good tolerability and encouraging glucose and body weight reduction across the dose levels tested compared to placebo