weight regain semaglutide and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension Trajectory of weight regain after

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It is well appreciated that accumulation of ectopic fat, especially in the liver, can lead to an insulin-resistant state predominantly mediated by negative-feedback interference on insulin signal transduction pathways 79,80

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Individual treatment decisions should be based on medical history, current evidence, medication availability, and provider judgment