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Effect of nicotine on the renal microcirculation in anesthetized rats: a potential for medullary hypoxic injury

High levels may indicate dehydration, kidney problems, a high carbohydrate diet, or adrenal stress

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Because it acts at the epithelial surface and is minimally absorbed, it is framed as a gut-restricted agent its intended pharmacology is at the tissue it touches, not throughout the body

10.1007/s00125-013-3132-5 229