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Once they reached the 2.4 mg dose, they remained on it for 68 weeks
Even safety data on TB-500 (synthetic TB4) is relatively scarce, with only a few studies reporting the potential side effects of its systemic application: In a 2010 study in 10 participants, TB4 caused occasional mild to moderate symptoms like headache and dizziness but no serious reactions or toxicities, even at doses up to 1260mg, administered daily for up to two weeks
This timeframe allows assessment of individual response, opportunity to adjust dosing, and generation of meaningful results without committing to an extended protocol
Factors such as side effect profiles, coexisting medical conditions, access, and cost must be considered
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subtilis encode this enzyme (Figure 1)
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