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However, animal studies have shown systemic effects with oral ingestion and caution is needed

Pediatric Use: Intake in children should be in the amount (0.5 to 3 mcg daily) recommended by the Food and Nutrition Board, National Academy of Science-National Research Council

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Although preliminary data are encouraging, especially regarding the reduction of inflammation and body weight, open questions remain regarding the effects of these drugs on a longer time scale and on different patient subgroups