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Aqueous solvents such as sterile water or bacteriostatic water are preferred for in vivo rodent studies because they eliminate the confounding variable of DMSO's own biological activity, which includes membrane permeabilization and anti-inflammatory effects

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Environmental Toxins Smoking disrupts blood flow, overstimulates the HPA axis, and raises cortisol, increasing blood glucose and inflammation

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Corticosteroid injections provide short-term relief but may not improve long-term outcomes and could potentially weaken the tendon with repeated use

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